protein

EphA2 Protein, Mouse (HEK293, His)

HY-P75240

5 μg;10 μg;50 μg;100 μg

45;72;185;300 USD

EphA2 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;72;185;300 USD

EphA2 protein is a receptor tyrosine kinase that promiscuously binds to ephrin A ligands to initiate bidirectional signaling. EphA2 is activated by ephrin-A1/EFNA1, regulates cell migration, adhesion, proliferation and differentiation, modulates DSG1 and inhibits ERK1/ERK2 signaling. EphA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA2 Protein, Mouse (HEK293, His) is 510 a.a., with molecular weight of ~65-95 kDa.

Mouse

The EphA2 protein, a receptor tyrosine kinase, engages in promiscuous binding to membrane-bound ephrin-A family ligands on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is known as forward signaling, while the pathway downstream of the ephrin ligand is termed reverse signaling. Activated by the ligand ephrin-A1/EFNA1, EphA2 plays a regulatory role in cell migration, integrin-mediated adhesion, proliferation, and differentiation. Additionally, EphA2 modulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibits the ERK1/ERK2 signaling pathway. It may also participate in UV radiation-induced apoptosis and exhibit a ligand-independent stimulatory effect on chemotactic cell migration. During development, EphA2 functions in various aspects of pattern formation and contributes to the development of several fetal tissues, including angiogenesis, early hindbrain development, and epithelial proliferation and branching morphogenesis during mammary gland development. Interaction with the ligand ephrin-A5/EFNA5 may regulate lens fiber cells' shape and interactions, playing a crucial role in lens transparency development and maintenance. Furthermore, in collaboration with ephrin-A2/EFNA2, EphA2 may contribute to bone remodeling by regulating osteoclastogenesis and osteoblastogenesis.

Ephrin type-A receptor 2; Epithelial cell kinase; EPHA2; ECK

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, 5%Trehalose, 5% Mannitol, 0.01%Tween-80, pH 7.4 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.