protein

Fc epsilon RIA/FCER1A Protein, Mouse (HEK293, Fc)

HY-P75212

5 μg;10 μg;100 μg

106;180;856 USD

Fc epsilon RIA/FCER1A Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;100 μg

106;180;856 USD

Fc epsilon RIA/FCER1A protein is a high-affinity receptor for immunoglobulin epsilon/IgE and is critical for mediating IgE effector function. It activates and differentiates myeloid cells after binding IgE and cross-linking with antigens/allergens, causing mast cells, basophils, and eosinophils to secrete mediators and cytokines. Fc epsilon RIA/FCER1A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Fc epsilon RIA/FCER1A protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

Fc epsilon RIA/FCER1A Protein is a high-affinity receptor for immunoglobulin epsilon/IgE. It plays a crucial role in mediating IgE effector functions in myeloid cells. Upon binding IgE and cross-linking with antigen/allergen, it initiates signaling pathways that activate and differentiate myeloid cells. This activation leads to the secretion of vasoactive amines, lipid mediators, and cytokines by mast cells, basophils, and eosinophils, which contribute to inflammatory responses, tissue remodeling, and cytotoxicity against microbes. The protein is responsible for triggering the immediate hypersensitivity response to allergens, acting as a host defense mechanism against helminth parasites, pathogenic bacteria, and venom toxicity. However, when dysregulated, it can cause harmful, life-threatening allergic and anaphylactic reactions. Structurally, Fc epsilon RIA/FCER1A Protein consists of a tetramer comprising an alpha chain, a beta chain, and two disulfide-linked gamma chains. It interacts with IGHE through its CH3 region.

Fc epsilon RI alpha; FCE1A; FCER1A; FcERI; FceRIa

Greater than 85% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.