protein

GRIK2 Protein, Human (HEK293, hFc)

HY-P75156

5 μg;10 μg;50 μg;100 μg

45;70;200;340 USD

GRIK2 Protein, Human (HEK293, hFc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;70;200;340 USD

GRIK2 is an ionotropic glutamate receptor that plays an important role in central nervous system synapses, responding to L-glutamate as an excitatory neurotransmitter. Upon binding of L-glutamate, GRIK2 undergoes a conformational change that opens cation channels that convert chemical signals into electrical impulses. GRIK2 Protein, Human (HEK293, hFc) is the recombinant human-derived GRIK2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GRIK2 Protein, Human (HEK293, hFc) is 530 a.a., with molecular weight of ~100-115 kDa.

Human

GRIK2, an ionotropic glutamate receptor, serves as a pivotal component in central nervous system synapses where L-glutamate acts as an excitatory neurotransmitter. Upon binding of L-glutamate, the receptor undergoes a conformational change, facilitating the opening of the cation channel and translating the chemical signal into an electrical impulse. Subsequently, the receptor swiftly desensitizes and enters a transient inactive state marked by the presence of bound agonist. Beyond its ionotropic glutamate receptor activity, GRIK2 plays a role in modulating the cell surface expression of NETO2 and functions as a thermoreceptor, conferring sensitivity to cold temperatures, particularly in dorsal root ganglion neurons.

Glutamate receptor ionotropic, kainate 2; GluK2; EAA4; GluR6

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.