protein

AMIGO2 Protein, Human (HEK293, His)

HY-P7495

10 μg;50 μg

125;350 USD

AMIGO2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

125;350 USD

AMIGO2 Protein, Human (HEK293, His) is an 58-85 kDa AMIGO2 protein fused His-tag expressed in HEK 293 cells. AMIGO2 Protein, Human (HEK293, His) interacts with PDK1 to activate the Akt pathway localizated to the plasma membrane [1] .

Human

AMIGO2 is a scaffold protein that regulates PDK1 membrane localization and Akt activation. This protein contains six leucine-rich repeats (LRRs), a single IgG-like domain, a transmembrane domain, and a cytosolic domain. AMIGO2 plays its role by controling PDK1 localization to the plasma membrane and then directly interacts with PDK1 to activate the Akt pathway [1] . Loss of AMIGO2 in endothelial cells (ECs) leads to apoptosis and inhibition of angiogenesis with Akt inactivation [1] . AMIGO2 is important in regulating T-cell functions, Amigo2-overexpression dampens NF-kB transcriptional activity, while Amigo2-deficiency enhances Akt but suppresses GSK-3β phosphorylation and promotes nuclear translocations of NF-kB and NFAT1 in Th-cells [1] .

rHuAmphoterin-Induced Protein 2, His; AMIGO2; Alivin-1; Amphoterin-Induced Protein 2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PB, pH 7.4.

Room temperature in continental US; may vary elsewhere.