Alpha-Galactosidase A Protein, Human (HEK293, His) | MedChem Express LLC HY-P7492 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

Alpha-Galactosidase A Protein, Human (HEK293, His)

catalog :

HY-P7492

quantity :

10 μg;50 μg

price :

135;380 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P7492

Product Name :

Alpha-Galactosidase A Protein, Human (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

10 μg;50 μg

List Price :

135;380 USD

list of Pubmed id :

406168002

Product Description :

Alpha-Galactosidase A Protein, Human (HEK293, His), a recombinant human alpha-Galactosidase A produced in HEK293 cells, has a His tag at the C-terminus. Alpha-Galactosidase A Protein, Human (HEK293, His) is the lysosomal exoglycosidase responsible for the hydrolysis of terminal α-galactosyl residues from glycoconjugates and is the defective enzyme causing Fabry disease [1] .

SpeciesSummary :

Human

Background :

alpha-Galactosidase A (α-GAL, also known as α-GAL A) is responsible for the breakdown of α-galactosides in the lysosome. Defects in human alpha-Galactosidase A lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of α-galactosylated substrates in the tissues. alpha-Galactosidase A is an active target of clinical research: there are currently two treatment options for Fabry disease, recombinant enzyme replacement therapy and pharmacological chaperone therapy [2] .

ALTnames :

rHualpha-Galactosidase A, His; GLA; alpha-Galactosidase A

Purity :

Greater than 95% as determined by reducing SDS-PAGE

Buffer :

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Storage :

Shipping with dry ice.

more info or order :

MedChem Express LLC product webpage