protein

HGF Protein, Canine (HEK293)

HY-P74889

2 μg;10 μg;50 μg;100 μg

35;100;280;450 USD

HGF Protein, Canine (HEK293)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;100;280;450 USD

HGF protein is a potent hepatocyte mitogen that stimulates mature hepatocyte proliferation and exhibits multiple growth factor properties in different tissues. As a ligand of MET receptor tyrosine kinase, HGF initiates downstream signaling cascades upon binding, activating MAPK signaling after TMPRSS13 cleavage. HGF Protein, Canine (HEK293) is the recombinant canine-derived HGF protein, expressed by HEK293 , with tag free.

Canine

HGF Protein emerges as a potent mitogen with hepatotrophic properties, specifically promoting the proliferation of mature parenchymal hepatocyte cells. Beyond its hepatocyte-centric functions, HGF acts as a versatile growth factor, exerting its effects across a broad spectrum of tissues and cell types. As an activating ligand for the receptor tyrosine kinase MET, HGF binds to MET, facilitating receptor dimerization and initiating downstream signaling cascades. Furthermore, following TMPRSS13 cleavage and activation, HGF activates MAPK signaling, contributing to its diverse cellular effects. Structurally, HGF exists as a dimer composed of an alpha chain and a beta chain linked by a disulfide bond. Notably, it interacts with SRPX2, enhancing HGF's mitogenic activity. This multifaceted functionality underscores the pivotal role of HGF in cellular growth, tissue homeostasis, and signal transduction pathways.

Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 6.2.

Room temperature in continental US; may vary elsewhere.