protein

HTRA2/OMI Protein, Human (His)

HY-P74876

5 μg;10 μg;50 μg

90;140;360 USD

HTRA2/OMI Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

90;140;360 USD

HTRA2/OMI, a serine protease, crucially induces cell death via multiple mechanisms.It directly inhibits BIRC proteins, intensifying caspase activity, and can also induce cell death through a BIRC-independent, caspase-independent pathway, relying on its serine protease activity.Additionally, during apoptosis, it cleaves THAP5, promoting its degradation.Notably, isoform 2 lacks apparent proteolytic activity.HTRA2/OMI Protein, Human (His) is the recombinant human-derived HTRA2/OMI protein, expressed by E.coli , with C-His labeled tag.

Human

HTRA2/OMI, a serine protease, exhibits proteolytic activity against a non-specific substrate, beta-casein. It plays a pivotal role in cell death induction through multiple mechanisms. One mechanism involves direct binding to and inhibition of BIRC proteins (inhibitor of apoptosis proteins, IAPs), leading to heightened caspase activity. Alternatively, HTRA2/OMI can induce cell death through a BIRC inhibition-independent, caspase-independent pathway, relying on its serine protease activity. Furthermore, during apoptosis, it cleaves THAP5, promoting its degradation. Notably, isoform 2 appears to lack proteolytic activity.

Serine protease HTRA2; Serine proteinase OMI; OMI; PRSS25

Greater than 87% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 0.3M NaCl, 1 mM DTT, 20% Glycerol, pH 7.8.

Shipping with dry ice.