protein

IdeS Protein, Streptococcus pyogenes (His, solution)

HY-P74867

5 μg;10 μg;50 μg

67;115;320 USD

IdeS Protein, Streptococcus pyogenes (His, solution)

proteins

E. coli

5 μg;10 μg;50 μg

67;115;320 USD

IdeS Protein is a highly specific IgG endopeptidase evolved from Streptococcus pyogenes, which can degrade IgG and participate in the immune response.IdeS Protein inhibits the function of certain neutrophil effectors, namely the production of reactive oxygen species (ROS), independently of IgG endopeptidase activity. IdeS Protein, Streptococcus pyogenes (His, solution) is the recombinant IdeS protein, expressed by E.coli , with N-10*His labeled tag.

Others

IdeS is a highly specific IgG endopeptidase evolved from Streptococcus pyogenes, which can not only degrade IgG but also directly or indirectly inhibit the innate immune response, thus promoting the survival of streptococcus in the inflammatory environment. IdeS was found to be identical to Mac-1 in Streptococcus, a protein thought to inhibit phagocytosis by inhibiting the recognition of IgG and/or complement configurations by the Fc receptor (CD16). IdeS/Mac-1 can inhibit the function of certain neutrophil effectors, namely the production of reactive oxygen species (ROS), independently of IgG endopeptidase activity [1] [2] .

Immunoglubulin-degrading enzyme; ideS

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of PBS, 50 % Glycerol, pH 6.6.

Shipping with dry ice