protein

IFN-gamma R2 Protein, Mouse (HEK293, His)

HY-P74852

5 μg;10 μg;50 μg

88;150;420 USD

IFN-gamma R2 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

88;150;420 USD

IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2 is the signal-transducing chain of the IFN-gamma receptor. IFN-gamma R2 forms the functional receptor with IFN-gamma R1. Upon binding with IFN-gamma, IFN-gamma R2 and IFN-gamma R1 oligomerize and transphosphorylate [1] . Then, the downstream signaling components JAK1 and JAK2 are phosphorylated and activated, and STAT1 is phosphorylated. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54) [2] . IFN-gamma R2 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R2 (M1-V243) with C-terminal His tag, which is produced in HEK293 cells.

Mouse

IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2. IFN-gamma R2 is highly expressed on myeloid cells, moderately on B cells and low on T cells, and the expression is regulated by the state of cellular differentiation or activation [2] . IFN-gamma R2 can associate with IFN-gamma R1 to form a functional receptor. Upon binding with IFN-gamma, IFN-gamma R2 and IFN-gamma R1 oligomerize and transphosphorylate [1] . Then, JAK1 and JAK2 are phosphorylated and activated, creating a binding site for STAT1. STAT1 is recruited to the receptor complex and leads to the phosphorylation. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54). IFN-gamma R2 is important for innating immune defense against mycobacterial infections. Defects in IFN-gamma R2 causes mendelian susceptibility to mycobacterial disease (MSMD) [2] . Human IFN-gamma R2 consists of extracellular domain (S28-Q247), helical domain (V248-F268), and cytoplasmic domain (L269-L337). IFN-gamma R2 plays a critical role in antimicrobial, and immune responses [2] .

Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.