protein

IGFBP-1 Protein, Canine (HEK293, His)

HY-P74849

2 μg;10 μg;50 μg

35;80;220 USD

IGFBP-1 Protein, Canine (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg

35;80;220 USD

IGFBP-1 Protein is a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factor (IGFs) I and II to extend the half-life of IGFs. IGFBP-1 inhibits proliferation, invasion, migration and apoptosis of HTR-8/SVneo cells by inducing MMP-26 expression. IGFBP1 may be a new prognostic factor and a target of molecular targeted therapy for gastric cancer. IGFBP-1 Protein, Canine (HEK293, His) is the recombinant canine-derived IGFBP-1 protein, expressed by HEK293 , with C-His labeled tag.

Canine

Insulin-like growth factor-binding protein 1 (IBP-1), also known as placental protein 12 (PP12), It's a protein encoded by the IGFBP1 gene. Igfbp-1 is a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factor (IGFs) I and II and circulates in plasma. The binding of the IGFBP-1 protein prolongs the half-life of IGFs and alters their interaction with cell surface receptors. IGFBP-1 can promote cell migration and has the same binding affinity for IGF1 and IGF2. IGFBP-1 inhibits proliferation, invasion, migration and apoptosis of HTR-8/SVneo cells by inducing MMP-26 expression. IGFBP1 may be a new prognostic factor and a target of molecular targeted therapy for gastric cancer [1] [2] [3] .

Insulin-like growth factor-binding protein 1; PP12; IBP-1;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.