protein

IL-21 Protein, Canine

HY-P74819

2 μg;10 μg;20 μg;50 μg;100 μg

35;90;150;280;450 USD

IL-21 Protein, Canine

proteins

E. coli

2 μg;10 μg;20 μg;50 μg;100 μg

35;90;150;280;450 USD

IL-21 is a potent immunoregulatory cytokine that orchestrates the delicate interplay between innate and adaptive immunity. It drives the production of IgG(1) and IgG(3) in B cells, which are critical for humoral immune responses, and plays a key role in T follicular helper (Tfh) cell generation and germinal center formation. IL-21 Protein, Canine is the recombinant canine-derived IL-21 protein, expressed by E. coli , with tag free.

Canine

IL-21, a cytokine endowed with potent immunoregulatory activity, emerges as a central orchestrator in the delicate interplay between innate and adaptive immunity. Exhibiting its versatile influence, IL-21 stimulates the production of IgG(1) and IgG(3) in B-cells, underscoring its crucial role in shaping humoral immune responses. The cytokine is intricately involved in the generation and maintenance of T follicular helper (Tfh) cells and the dynamic formation of germinal centers. Collaborating synergistically with IL6, IL-21 assumes a pivotal role in steering the early development of Tfh cells, proving indispensable for mounting an effective antibody response during acute viral infections. Extending its regulatory reach, IL-21 may contribute to the proliferation and maturation of natural killer (NK) cells, working in concert with IL15. Furthermore, IL-21 exerts a regulatory hand in controlling the proliferation of mature B- and T-cells in response to activating stimuli. In tandem with IL15 and IL18, it stimulates the production of interferon-gamma in both T-cells and NK cells, adding layers to its intricate regulatory functions. Notably, during T-cell-mediated immune responses, IL-21 emerges as a potential inhibitor, curbing the activation and maturation of dendritic cells, further highlighting its nuanced role in immune modulation.

Interleukin-21; Il21; Za11

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.

Room temperature in continental US; may vary elsewhere.