protein

IL-2R gamma/CD132 Protein, Rat (HEK293, His)

HY-P74805

2 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

IL-2R gamma/CD132 Protein, Rat (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma takes part in inflammatory response and mediates activation of the cells [1] [2] . IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types [3] . IL-2R gamma/CD132 Protein, Rat (HEK293, His) is a recombinant rat extracellular region of IL-2R beta (M1-A262) with a C-Terminal His tag, which is produced in HEK293 cells.

Rat

IL-2R gamma (CD132), a receptor for IL-2, is a member of the type I cytokine receptor family and type 5 subfamily. IL-2R gamma is expressed in spleen and thymus [1] . The sequence of amino acids in IL-2R beta differs in different species. Rats IL-2R gamma shares 80.70% aa sequence identity with mice. Rats IL-2R gamma shares IL-2R gamma has low-affinity for IL-2, but has intermediate affinity for IL-2 when forming heterodimer with IL-2R beta. IL-2R beta/gama heterodimer complex transduces a signal when IL-2 concentrations are relatively high [2] . IL-2R gamma can be utilized by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor, and takes part in the development, activation, proliferation, differentiation and regulation of lymphocytes [3] . IL-2R gamma also affects the development of NK and B cells in rats [4] . IL-2R gamma is involved in inflammatory response, and mediates activation of the cells [1] .

Cytokine receptor common subunit gamma; IL-2RG; p64; CD132

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.