protein

MDH1 Protein, Rat (His)

HY-P74757

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

MDH1 Protein, Rat (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

MDH1 Protein, an enzyme, is involved in the citric acid cycle and the conversion of malate to oxaloacetate.Dysregulation of MDH1 Protein has been associated with metabolic disorders and cancer.Targeting MDH1 Protein may provide potential therapeutic interventions by modulating energy metabolism, inhibiting tumor growth, and potentially treating these conditions.MDH1 Protein, Rat (His) is the recombinant rat-derived MDH1 protein, expressed by E.coli , with C-His labeled tag.

Rat

The MDH1 protein, an important enzyme, is responsible for catalyzing the reduction of aromatic alpha-keto acids when NADH is present. It serves critical functions in both the malate-aspartate shuttle and the tricarboxylic acid cycle, which are crucial for providing mitochondrial NADH supply needed for oxidative phosphorylation. Additionally, MDH1 catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, a process that can result in increased levels of reactive oxygen species (ROS).

Malate Dehydrogenase Cytoplasmic; Cytosolic Malate Dehydrogenase; MDH1; MDHA

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCL, 300 mM NaCl, pH 7.4, 10% Glycerol.

Room temperature in continental US; may vary elsewhere.