protein

MDM4/MDMX Protein, Human (His)

HY-P74756

5 μg;10 μg;50 μg

80;140;380 USD

MDM4/MDMX Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

80;140;380 USD

MDM4/MDMX proteins cooperate with MDM2 to regulate TP53 (p53) and inhibit the transcriptional activation domains of p53 and p73. This hinders their ability to induce cell cycle arrest and apoptosis. MDM4/MDMX Protein, Human (His) is the recombinant human-derived MDM4/MDMX protein, expressed by E. coli , with N-His labeled tag.

Human

MDM4/MDMX Protein collaborates with MDM2 in regulating TP53 (p53). It functions by inhibiting the transcriptional activation domain of p53 and p73, thereby impeding their ability to induce cell cycle arrest and apoptosis. Moreover, MDM4 hinders the degradation of MDM2 and can reverse MDM2-mediated degradation of TP53 while concurrently suppressing TP53 transactivation and apoptotic functions. The protein forms a trimeric complex with MDM2 and USP2 and interacts with TP53, TP73, and USP2. Notably, when phosphorylated, MDM4 interacts with YWHAG, exerting a negative regulatory effect on its activity towards TP53. These interactions highlight the intricate role of MDM4 in modulating key components of the TP53 pathway, contributing to the finely tuned regulation of cellular responses to stress and DNA damage.

Protein Mdm4; Protein Mdmx; MDM4; MDMX

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.8.

Room temperature in continental US; may vary elsewhere.