protein

MVK Protein, Human (sf9, His-GST)

HY-P74739

5 μg;10 μg

125;214 USD

MVK Protein, Human (sf9, His-GST)

proteins

Sf9 insect cells

5 μg;10 μg

125;214 USD

MVK (mevalonate kinase) protein plays a vital role in cellular metabolism by catalyzing the phosphorylation of mevalonate to mevalonate 5-phosphate, which is responsible for isoprenoid and cholesterol biosynthesis. key step. MVK regulates pathways necessary for the synthesis of important cellular components. MVK Protein, Human (sf9, His-GST) is the recombinant human-derived MVK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of MVK Protein, Human (sf9, His-GST) is 396 a.a., with molecular weight of ~47 kDa.

Human

The MVK protein plays a pivotal role in isoprenoid and cholesterol biosynthesis by catalyzing the phosphorylation of mevalonate to mevalonate 5-phosphate. This enzymatic activity represents a crucial and rate-limiting step in the mevalonate pathway, a metabolic pathway essential for the synthesis of various important molecules, including cholesterol and isoprenoid compounds. The phosphorylation of mevalonate by MVK is a tightly regulated process and a key regulatory point in the overall control of cholesterol and isoprenoid production within cells. Dysregulation of MVK activity has been associated with certain metabolic disorders, emphasizing the significance of this enzyme in maintaining cellular homeostasis and lipid metabolism.

Mevalonate kinase; MK; MVK

Greater than 85% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH 7.4, 10% gly.

Shipping with dry ice