protein

AKR1C4 Protein, Human (His)

HY-P7470

10 μg;50 μg

150;420 USD

AKR1C4 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

150;420 USD

406167990

AKR1C4 Protein, Human (His) is a human recombinant AKR1C4 with a N-Terminal His-tag. AKR1C4 Protein, Human (His) is derived from E. coli and corresponding to the amino acids 1-323 of human Aldo-keto Reductase 1C4/AKR1C4.

Human

Aldo-keto Reductase 1C4 (AKR1C4) is a member of the aldo-keto reductase (AKR) superfamily. AKR1C4 catalyzes the reversible oxidoreduction of various 3α-hydroxysteroids and prostaglandins as well as the oxidation of trans‑dihydrodiols of aromatic hydrocarbons and alicyclic alcohols. AKR1C4 acts as NADPH-dependent 3-, 17- and 20-ketosteroid reductases and as 3α-, 17β- and 20α-hydroxysteroid oxidases. AKR1C4 reduces 11-ketodihydrotestosterone (11KDHT) to both 3α- and 3β-hydroxy metabolites. AKR1C4 is important for steroid hormone metabolism primarily through synthesis and clearance of testosterone. AKR1C4 is virtually liver-specific and its high Kcat/Km allows this enzyme to form 5α/5β-tetrahydrosteroids robustly [1] [2] .

rHuAldo-keto Reductase 1C4, His; AKR-1C4; Aldo-keto Reductase 1C4

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM Tris, 150 mM NaCl, pH 8.0 or 20 mM Tris-HCl, 150 mM NaCl, 10% Sucrose, 0.05% Tween 80, pH 9.0.

Shipping with dry ice