protein

Nicastrin Protein, Human (HEK293, His)

HY-P74698

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

Nicastrin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

Nicastrin Protein, a crucial gamma-secretase complex subunit, catalyzes intramembrane cleavage of Notch receptors and APP.Operating in Notch and Wnt signaling, the complex modulates regulatory proteins and CTNNB1 levels.Collaborating with PSEN1/2, APH1A/B, and PSENEN/PEN2, Nicastrin binds to proteolytically processed C83 and C99 fragments, emphasizing its pivotal role in molecular pathways and cellular processes.Nicastrin Protein, Human (HEK293, His) is the recombinant human-derived Nicastrin protein, expressed by HEK293 , with C-His labeled tag.

Human

Nicastrin protein is an essential subunit of the gamma-secretase complex, an endoprotease assembly pivotal for catalyzing the intramembrane cleavage of integral membrane proteins, including Notch receptors and amyloid-beta precursor protein (APP). Operating in Notch and Wnt signaling cascades, the gamma-secretase complex regulates downstream processes by processing key regulatory proteins and modulating cytosolic CTNNB1 levels. As a fundamental component of the gamma-secretase complex, Nicastrin collaborates with a presenilin homodimer (PSEN1 or PSEN2), APH1 (APH1A or APH1B), and PSENEN/PEN2 to form the functional complex. This intricate molecular machinery binds to proteolytically processed C-terminal fragments C83 and C99 of APP and engages in interactions with PSEN1 and PSEN2, underscoring its significant role in molecular pathways and cellular processes.

Nicastrin; NCSTN; KIAA0253

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.