protein

AGER Protein, Human (HEK293, His)

HY-P7467

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

42;67;180;325;700;1200;1750 USD

AGER Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

42;67;180;325;700;1200;1750 USD

405076101

AGER Protein, Human (HEK293, His) is human recombinant AGER with a His tag at the C-terminus. AGER Protein, Human (HEK293, His) is expressed by mammalian expression system and the target gene encoding Ala23-Ala344 is expressed.

Human

AGER (Advanced glycosylation end product-specific receptor), a member of the immunoglobulin superfamily of cell surface molecules, is a transmembrane signal transduction receptor with a number of ligands, including alarmins that can initiate and perpetuate immune responses. AGER naturally exists in two forms that are full-length membrane-bound and truncated (soluble). The human AGER is a highly polymorphic gene with more than 190 SNPs mapped to its locus on the 6p21.3 chromosome. AGER interacts with a broad spectrum of ligands and multiple signaling pathways, such as those activated by the high mobility group box 1 (HMGB1) protein (a non-canonical ligand of AGER). AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes [1] [2] .

rHuAGER, His; RAGE; AGER

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.0.

Room temperature in continental US; may vary elsewhere.