protein

p67phox Protein, Human (sf9, His-GST)

HY-P74655

5 μg;10 μg;50 μg;100 μg

65;105;290;465 USD

p67phox Protein, Human (sf9, His-GST)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg;100 μg

65;105;290;465 USD

p67phox is central to the activation of NADPH oxidase, which is critical for superoxide production. p67phox forms heterodimers with CYBA and CYBB and interacts with NCF4 and NCF1 to establish important connections within the complex. p67phox Protein, Human (sf9, His-GST) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p67phox Protein, Human (sf9, His-GST) is 526 a.a., with molecular weight of 80-90 kDa.

Human

The p67phox protein plays a pivotal role in the activation of the latent NADPH oxidase, a process essential for superoxide production. As a key component of the NADPH oxidase complex, it forms a heterodimer with the membrane proteins CYBA and CYBB, alongside the cytosolic subunits NCF1, NCF2, and NCF4. Notably, p67phox interacts with NCF4 and NCF1, establishing crucial connections within the complex through its C-terminal SH3 domain. Additionally, it engages with SYTL1 and RAC1 and may interact with NOXO1, highlighting its versatility in associating with regulatory elements. Further interactions with S100A8, calprotectin (S100A8/9), and GBP7 underscore the intricate network involved in the regulation of NADPH oxidase activity. The interaction with CYBB is enhanced in the presence of GBP7, emphasizing the dynamic nature of these protein-protein associations in orchestrating superoxide generation.

Neutrophil cytosol factor 2; NCF-2; NOXA2; P67PHOX

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM Nacl, 10% Glycerol, pH 7.4.

Shipping with dry ice