protein

PDGF-CC Protein, Cynomolgus (HEK293, hFc)

HY-P74640

2 μg;10 μg;50 μg;100 μg

35;80;225;380 USD

PDGF-CC Protein, Cynomolgus (HEK293, hFc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;80;225;380 USD

Platelet derived growth factor C (PDGF-CC) is a growth factor that plays an essential role in the regulation of cell proliferation, cell migration, survival and chemotaxis. PDGF-CC is a potent mitogen and chemoattractant for cells of mesenchymal origin which plays an important roll in normal skeleton formation and normal skin morphogenesis during embryonic development, wound healing, angiogenesis and blood vessel development as well as being involved in fibrotic processes. PDGF-CC Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGF-CC Protein, Cynomolgus (HEK293, hFc) is 111 a.a., with molecular weight of ~45 kDa.

Cynomolgus

Platelet derived growth factor C (PDGF-CC) is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGF-CC is a potent mitogen and chemoattractant for cells of mesenchymal origin which is required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. PDGF-CC is also required for normal skin morphogenesis during embryonic development. PDGF-CC plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. PDGF-CC plays an important role in angiogenesis and blood vessel development and is involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain of PDGF-CC has mitogenic activity in coronary artery smooth muscle cells [1] [2] [3] .

PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.