protein

PIGR Protein, Mouse (HEK293, His)

HY-P74631

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

PIGR Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

PIGR proteins mediate the selective transcytosis of polymerized IgA and IgM across mucosal epithelial cells.It binds to these immunoglobulins at the basolateral surface, forming complexes that are transported intracellularly and secreted at the apical surface.PIGR Protein, Mouse (HEK293, His) is the recombinant mouse-derived PIGR protein, expressed by HEK293 , with C-His labeled tag.

Mouse

The PIGR protein serves as a crucial mediator in the selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. At the basolateral surface of epithelial cells, it binds to polymeric IgA and IgM, forming a complex that undergoes transportation across the cell to be ultimately secreted at the apical surface. Throughout this transcytosis process, a cleavage event separates the extracellular segment, known as the secretory component, from the transmembrane segment. PIGR, through its N-linked glycans, ensures the anchoring of secretory IgA (sIgA) molecules to the mucus lining the epithelial surface, contributing to the neutralization of extracellular pathogens. In its free form, PIGR may also act as a non-specific microbial scavenger, playing a role in preventing pathogen interaction with epithelial cells.

Polymeric Immunoglobulin Receptor; Poly-Ig Receptor; PIGR

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.