protein

PLTP Protein, Human (HEK293, His)

HY-P74625

10 μg

230 USD

PLTP Protein, Human (HEK293, His)

proteins

HEK293

10 μg

230 USD

PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-His labeled tag.

Human

PLTP Protein assumes a central role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low-density lipoproteins or LDL and very low-density lipoproteins or VLDL) into high-density lipoproteins (HDL), as well as facilitating the exchange of phospholipids among triglyceride-rich lipoproteins. This extensive lipid transfer encompasses various molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside, and phosphatidyl ethanolamine. PLTP further plays a crucial role in remodeling HDL, influencing its size and composition. Additionally, the protein is a key player in the uptake of cholesterol from peripheral cells and tissues, facilitating its transport to the liver for degradation and excretion. Notably, two distinct forms of PLTP exist in plasma: an active form capable of transferring phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form lacking this capability, contributing to the nuanced regulation of lipid homeostasis.

Phospholipid transfer protein; Lipid transfer protein II; PLTP

Greater than 80% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.