protein

PON3 Protein, Human (S50N, sf9, His)

HY-P74623

5 μg;10 μg;50 μg;100 μg

46;75;210;340 USD

PON3 Protein, Human (S50N, sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg;100 μg

46;75;210;340 USD

PON3 is less active against organophosphates and aromatic carboxylic acid esters and is particularly capable of rapidly hydrolyzing lactones, including statin precursors such as lovastatin. It is capable of hydrolyzing aromatic lactones and specific 5- or 6-membered ring lactones, but is less efficient for simple or polar substituted lactones. PON3 Protein, Human (S50N, sf9, His) is the recombinant human-derived PON3 protein, expressed by Sf9 insect cells , with N-His labeled tag.

Human

PON3 displays low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Notably, it exhibits rapid hydrolysis of lactones, including statin prodrugs like lovastatin. Moreover, PON3 is capable of hydrolyzing aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents, while it does not efficiently hydrolyze simple lactones or those with polar substituents. These substrate specificities highlight PON3's role in the metabolism of certain ester compounds and lactones, providing insights into its enzymatic activities and potential implications in drug metabolism.

Serum paraoxonase/lactonase 3; PON3

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 1 mM CaCl 2 , 10% Glycerol, 0.1% DDM.

Shipping with dry ice