protein

PRC1 Protein, Human (sf9, His)

HY-P74620

5 μg;10 μg;50 μg

180;300;850 USD

PRC1 Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg

180;300;850 USD

PRC1 is a key regulator of cytokinesis, coordinating midzone formation and successful cell division by cross-linking microtubules and recruiting essential proteins such as KIF14, PLK1 and ECT2. Its effects extend to tumorigenesis, promoting bladder cancer cell proliferation and inhibiting apoptosis. PRC1 Protein, Human (sf9, His) is the recombinant human-derived PRC1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of PRC1 Protein, Human (sf9, His) is 620 a.a., with molecular weight of ~75 kDa.

Human

PRC1, a pivotal regulator of cytokinesis, plays a crucial role in orchestrating the spatiotemporal formation of the midzone and ensuring successful cytokinesis by cross-linking antiparallel microtubules at an average distance of 35 nM. Its indispensability extends to the recruitment of key proteins such as KIF14, PLK1, and ECT2 to the central spindle and midbody, essential steps for proper cell division. In addition to its fundamental role in cellular processes, PRC1 exhibits oncogenic properties, promoting proliferation, inhibiting apoptosis, and contributing to the carcinogenic progression of bladder cancer cells. As a homodimer, PRC1 interacts with various proteins, including RACGAP1, CENPE, KIF4A, KIF23, and PLK1, forming a complex network of molecular interactions crucial for its multifaceted functions during mitosis. The intricate interplay of PRC1 with these proteins underscores its significance in the intricate machinery governing cell division and highlights its potential as a target for therapeutic interventions in cancer.

Protein regulator of cytokinesis 1; PRC1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 20% Glycerol, 3 mM DTT. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Shipping with dry ice