protein

RACK1 Protein, Human (His-MBP)

HY-P74606

5 μg;10 μg;50 μg;100 μg

42;70;200;340 USD

RACK1 Protein, Human (His-MBP)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

42;70;200;340 USD

The RACK1 protein is a multifunctional scaffold protein that participates in multiple cellular processes by recruiting, assembling, and regulating signaling molecules. As part of the 40S ribosomal subunit, it contributes to translation repression and initiates the ribosome quality control (RQC) pathway by promoting ubiquitination of specific 40S ribosomal subunits. RACK1 Protein, Human (His-MBP) is the recombinant human-derived RACK1 protein, expressed by E. coli , with N-His, N-MBP labeled tag. The total length of RACK1 Protein, Human (His-MBP) is 317 a.a., with molecular weight of ~70 kDa.

Human

RACK1, functioning as a versatile scaffolding protein, intricately participates in diverse cellular processes by recruiting, assembling, and regulating various signaling molecules. As a component of the 40S ribosomal subunit, it contributes to translational repression and is pivotal in initiating the ribosome quality control (RQC) pathway, particularly by promoting the ubiquitination of a subset of 40S ribosomal subunits. RACK1 binds and stabilizes activated protein kinase C (PKC), thereby enhancing PKC-mediated phosphorylation and potentially recruiting it to the ribosome for the phosphorylation of EIF6. Furthermore, RACK1 exerts inhibitory effects on SRC kinases, including SRC, LCK, and YES1, leading to cell cycle arrest at the G0/G1 phase. Its regulatory role extends to diverse cellular functions, such as modulating integrin signaling, promoting apoptosis, regulating membrane localization of various receptors, and influencing cell migration. Additionally, RACK1 is implicated in pathogen-host interactions, as evidenced by its binding to Yersinia pseudotuberculosis yopK, resulting in the inhibition of phagocytosis and facilitating bacterial survival within host cells.

Receptor of activated protein C kinase 1; HLC-7; RACK1; GNB2L1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.