protein

RAMP3 Protein, Human (HEK293, hFc)

HY-P74603

5 μg;10 μg;50 μg;100 μg

50;80;215;340 USD

RAMP3 Protein, Human (HEK293, hFc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

50;80;215;340 USD

RAMP3 protein plays a crucial role in cardioprotection by attenuating cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. RAMP3 is multifunctional, promoting the transport of CALCRL and GPER1 to the plasma membrane and coordinating membrane-associated signaling. RAMP3 Protein, Human (HEK293, hFc) is the recombinant human-derived RAMP3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of RAMP3 Protein, Human (HEK293, hFc) is 95 a.a., with molecular weight of 45-60 kDa.

Human

RAMP3 emerges as a key participant in cardioprotection, exerting its influence by mitigating cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Functionally versatile, RAMP3 facilitates the transportation of the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane, underscoring its role in orchestrating membrane-associated signaling events. Additionally, RAMP3 serves as a receptor for adrenomedullin (AM) alongside CALCRL, forming a heterodimeric complex that engages in molecular interactions crucial for mediating the effects of AM. The intricate interplay of RAMP3 with GPER1 further highlights its involvement in diverse cellular pathways and underscores its significance in cardiovascular physiology.

Receptor activity-modifying protein 3; RAMP3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.