protein

SHP-2 Protein, Mouse (HEK293, His)

HY-P74549

5 μg;10 μg;50 μg;100 μg

43;74;206;350 USD

SHP-2 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

43;74;206;350 USD

SHP-2 Protein functions downstream of diverse receptor and cytoplasmic tyrosine kinases, participating in signal transduction from the cell surface to the nucleus.It positively regulates the MAPK pathway and dephosphorylates key proteins like GAB1, ARHGAP35, EGFR, ROCK2, CDC73, and SOX9.Additionally, SHP-2 dephosphorylates NEDD9/CAS-L to modulate cellular processes.SHP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHP-2 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

SHP-2 protein functions downstream of various receptor and cytoplasmic protein tyrosine kinases, participating in signal transduction from the cell surface to the nucleus. It positively regulates the MAPK signal transduction pathway and exhibits dephosphorylation activity towards substrates such as GAB1, ARHGAP35, EGFR, ROCK2 (at 'Tyr-722,' enhancing its RhoA binding activity), CDC73, and tyrosine-phosphorylated NEDD9/CAS-L. Notably, SHP-2 plays a role in the inactivation of SOX9 by dephosphorylating its tyrosine residues, leading to the promotion of ossification. Through its multifaceted dephosphorylation activities, SHP-2 is a critical player in modulating key signaling pathways involved in cell growth, differentiation, and cellular responses to various stimuli.

Tyrosine-protein phosphatase non-receptor type 11; SH-PTP2; SHP-2; Ptpn11

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.