protein

SIGIRR Protein, Mouse (HEK293, His)

HY-P74547

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

SIGIRR Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

SIGIRR protein negatively regulates the Toll-like pathway and IL-1R pathway by inhibiting the recruitment of TLR4.SIGIRR disrupts Il1R1 and IL1RAP heterodimerization through its extracellular domain.SIGIRR Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived SIGIRR protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

Mouse

SIGIRR Protein serves as a negative regulator within the Toll-like and IL-1R receptor signaling pathways, exerting its inhibitory effects by attenuating the recruitment of receptor-proximal signaling components to the TLR4 receptor, possibly through a TIR-TIR domain interaction with TLR4. Additionally, through its extracellular domain, SIGIRR interferes with the heterodimerization of Il1R1 and IL1RAP. The protein interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, and TRAF6, and upon IL-1 stimulation, it is found in a complex with IL1R1, SIGIRR, MYD88, IRAK1, and TRAF6. Moreover, upon stimulation with LPC, SIGIRR is part of a complex that includes TLR4, SIG1IR, MYD88, IRAK1, and TRAF6. It also interacts with PALM3, suggesting a multifaceted role in modulating inflammatory signaling pathways.

Single Ig IL-1-related receptor; Toll/interleukin-1 receptor 8; TIR8

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.