protein

TFF3 Protein, Human (HEK293, His)

HY-P74529

50 μg

360 USD

TFF3 Protein, Human (HEK293, His)

proteins

HEK293

50 μg

360 USD

Trefoil factor 3 (TFF3) is a small peptide (59 amino acids; 7 kDa) that is a member of the trefoil family and a stable secretory protein expressed in gastrointestinal mucosa, playing a role in restitution and regeneration of epithelia. The mode of action of Tff3 ranges from a simple increase in mucous viscosity, cytoprotection, and antiapoptotic and chemotactic effects to more complex immune regulatory functions, and has a strong association with tumorigenesis. TFF3 Protein, Human (HEK293, His) is the recombinant human-derived TFF3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TFF3 Protein, Human (HEK293, His) is 59 a.a., with molecular weight of ~8 kDa.

Human

Trefoil factor 3 (TFF3) is a small peptide (59 amino acids; 7 kDa) that is a member of the trefoil family which are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides with three-loop structure. TFF3 is a stable secretory protein expressed in gastrointestinal mucosa, playing a role in restitution (cell migration to heal superficial lesions) and regeneration (differentiation and proliferation as repair) of epithelia, being involved in the maintenance and repair of the intestinal mucosa and promotes the mobility of epithelial cells in healing processes. The mode of action of Tff3 ranges from a simple increase in mucous viscosity, cytoprotection, and antiapoptotic and chemotactic effects to more complex immune regulatory functions. Tff expression patterns are altered in various tumors, implying a strong association with tumorigenesis. Tff3 presents in the bloodstream and various other organs, including the liver, brain, pancreas, and lymphoid tissue [1] [2] [3] .

Trefoil factor 3; Intestinal trefoil factor; mITF; Tff3; Itf

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.