protein

TIGIT Protein, Rat (HEK293, Fc)

HY-P74513

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;75;200;340;950;1620 USD

TIGIT Protein, Rat (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;75;200;340;950;1620 USD

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins, binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation or T cell dependent B cell responses by promoting the generation of mature immunoregulatory dendritic cells. TIGIT Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

Rat

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins, containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif. TIGIT binds with high affinity to PVR which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation or T cell dependent B cell responses by promoting the generation of mature immunoregulatory dendritic cells. TIGIT is expressed on several classes of T cells including follicular B helper T cells (TFH) [1] .

T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.