protein

TNFRSF1A Protein, Rat (HEK293, His)

HY-P74504

2 μg;10 μg;50 μg;100 μg

35;75;200;340 USD

TNFRSF1A Protein, Rat (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;75;200;340 USD

TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus [1] .

Rat

TNFRSF1A (TNF RI) protein is a single-pass type I membrane protein belonging to the tumor necrosis factor (TNF) family. TNFRSF1A is the major signaling receptor for TNF-α. TNFRSF1A protein is a multifunctional cytokine, which is synthesized by almost all cells [1] [2] . The sequence of amino acids in TNFRSF1A from different species is very different (less than 85% similarity among human, rat and mouse). TNFRSF1A contains a protein-protein interaction domain, called death domain (DD), can recruit other DD-containing proteins and couples the death receptors to caspase activation and apoptosis. Both soluble and membrane-bound forms of the cytokine can activate TNFRSF1A. TNFRSF1A induces cellular inflammatory damage and apoptosis by participating in mTOR, JNK, IKK, caspase 3, MAPK, and NF-κB pathways [1] [3] [4] .

Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.