product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
PGD Protein, Human (HEK293, His)
catalog :
HY-P7450
quantity :
10 μg;50 μg
price :
75;210 USD
more info or order :
product information
Catalog Number :
HY-P7450
Product Name :
PGD Protein, Human (HEK293, His)
Product Type :
proteins
Host Species :
HEK293
Size :
10 μg;50 μg
List Price :
75;210 USD
list of Pubmed id :
405021316
Product Description :
PGD Protein, Human (HEK293, His) is a homodimeric protein, with an N-terminal His tag. Recombinant Human PGD, His (HEK293-expressed) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP + as cofactor in the pentose phosphate pathway (PPP) [1] .
SpeciesSummary :
Human
Background :
PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of PGD remains elusive. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP + and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. In addition, 6PGD pY481 is associated with Fyn expression, the malignancy and prognosis of human glioblastoma. These findings establish a critical role of Fyn-dependent 6PGD phosphorylation in EGF-promoted tumor growth and radiation resistance [1] .
ALTnames :
rHuPGD, His; 6-phosphogluconate dehydrogenase, decarboxylating; PGD
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.2 μm filter solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA