protein

UBASH3B/STS1 Protein, Human (His)

HY-P74484

5 μg;10 μg;50 μg;100 μg

53;90;255;430 USD

UBASH3B/STS1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

53;90;255;430 USD

UBASH3B/STS1 protein blocks CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases, leading to the accumulation of activating receptors such as T cell receptors and EGFR on the cell surface. It exhibits tyrosine phosphatase activity against substrates such as EGFR, FAK, SYK and ZAP70. UBASH3B/STS1 Protein, Human (His) is the recombinant human-derived UBASH3B/STS1 protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of UBASH3B/STS1 Protein, Human (His) is 268 a.a., with molecular weight of ~30 kDa.

Human

UBASH3B/STS1 protein disrupts the CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases, leading to the accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Additionally, it demonstrates tyrosine phosphatase activity towards multiple substrates, including EGFR, FAK, SYK, and ZAP70. Furthermore, UBASH3B/STS1 participates in the down-regulation of proteins that undergo dual modification involving both protein tyrosine phosphorylation and ubiquitination.

Ubiquitin-associated and SH3 domain-containing protein B; STS-1; TULA-2; UBASH3B

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 6.8.

Room temperature in continental US; may vary elsewhere.