protein

14-3-3 sigma Protein, Mouse

HY-P74438

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;1100 USD

14-3-3 sigma Protein, Mouse

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;1100 USD

14-3-3 sigma proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity. When bound to KRT17, it stimulates the regulation of protein synthesis and cell growth through the Akt/mTOR pathway. 14-3-3 sigma Protein, Mouse is the recombinant mouse-derived 14-3-3 sigma protein, expressed by E. coli , with tag free. The total length of 14-3-3 sigma Protein, Mouse is 248 a.a., with molecular weight of ~32 kDa.

Mouse

The 14-3-3 sigma protein functions as an adapter implicated in the regulation of a broad spectrum of both general and specialized signaling pathways, engaging with numerous partners through the recognition of phosphoserine or phosphothreonine motifs, thereby modulating the activity of the binding partner. Particularly, when bound to KRT17, it plays a role in regulating protein synthesis and epithelial cell growth by stimulating the Akt/mTOR pathway. Additionally, it may regulate MDM2 autoubiquitination and degradation, leading to the activation of p53/TP53. Existing as a homodimer, 14-3-3 sigma is found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, and VPS35, and it interacts with various proteins, including GAB2, KRT17, SAMSN1, SRPK2, COPS6, COP1 (leading to proteasomal degradation), the 'Thr-369' phosphorylated form of DAPK2, PI4KB, SLITRK1, and LRRK2 (dependent on LRRK2 phosphorylation). These diverse interactions highlight the versatile role of 14-3-3 sigma in orchestrating various cellular processes and signaling events.

14-3-3 protein sigma; HME1; SFN; Stratifin; Mkrn3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.