protein

ACE2 Protein, Mouse (HEK293, His-Fc)

HY-P74433

5 μg;10 μg

150;255 USD

ACE2 Protein, Mouse (HEK293, His-Fc)

proteins

HEK293

5 μg;10 μg

150;255 USD

ACE2 protein is an important carboxypeptidase in the renin-angiotensin system, which can regulate blood volume and vascular resistance and maintain cardiovascular homeostasis. It converts angiotensin I to the antihypertrophic angiotensin 1-9 and angiotensin II to the vasodilatory angiotensin 1-7, thereby opposing vasoconstriction. ACE2 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived ACE2 protein, expressed by HEK293 , with C-hFc, C-His, C-8*His labeled tag. The total length of ACE2 Protein, Mouse (HEK293, His-Fc) is 723 a.a., with molecular weight of ~130 kDa.

Mouse

ACE2, an essential counter-regulatory carboxypeptidase within the renin-angiotensin hormone system, serves as a critical regulator of blood volume and systemic vascular resistance, contributing to cardiovascular homeostasis. Its enzymatic activity includes the conversion of angiotensin I to angiotensin 1-9, a peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, known for its vasodilatory and anti-proliferative properties, thereby counteracting the vasoconstrictor actions of angiotensin II. ACE2 further plays a role in amino acid transport, acting as a binding partner for the amino acid transporter SLC6A19, regulating its cell surface trafficking and activity. Additionally, ACE2 contributes to the regulation of various vasoactive peptides, such as neurotensin, kinetensin, and des-Arg bradykinin, as well as other biological peptides like apelins, casomorphins, and dynorphin A. Its multifaceted functions position ACE2 as a pivotal player in cardiovascular and amino acid homeostasis.

Angiotensin-converting enzyme 2; ACE-2; ACEH; ACE-related carboxypeptidase

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, 1 mM ZnCl 2 , pH 7.5 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.