protein

ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His)

HY-P74430

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

50;85;220;350;1050;1780 USD

ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

50;85;220;350;1050;1780 USD

The acid prostatic phosphatase (ACPP) protein, encapsulated in virus-like particles (VLPs), is an acid tyrosine phosphatase that skillfully dephosphorylates a variety of substrates. ACPP-VLP possesses lipid phosphatase activity and inactivates lysophosphatidic acid. ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His) is the recombinant mouse-derived ACPP/Prostatic Acid Phosphatase protein, expressed by HEK293 , with C-His labeled tag. The total length of ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His) is 350 a.a., with molecular weight of 44-55 kDa.

Mouse

Prostatic Acid Phosphatase (ACPP) protein serves as a versatile non-specific tyrosine phosphatase, exhibiting its catalytic activity under acidic conditions (pH 4-6) on a broad range of substrates, including alkyl, aryl, and acyl orthophosphate monoesters, as well as phosphorylated proteins. Notably, ACPP also displays lipid phosphatase activity, contributing to the inactivation of lysophosphatidic acid in seminal plasma. Beyond its tyrosine phosphatase functions, ACPP demonstrates ecto-5'-nucleotidase activity in dorsal root ganglion neurons, leading to the generation of adenosine from AMP. This extracellular adenosine, in turn, contributes to a reduction in chronic pain by activating A1R in nociceptive neurons. The multifaceted enzymatic activities of ACPP highlight its potential significance in various cellular processes and its therapeutic implications, particularly in pain management.

ACP-3; ACPP; Prostatic Acid Phosphatase; PAPf39; PAP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.