protein

Adrenomedullin/ADM Protein, Human (HEK293, Fc)

HY-P74426

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;290;500;1400 USD

Adrenomedullin/ADM Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;290;500;1400 USD

Adrenomedullin (ADM) and PAMP are potent hypotensive and vasodilator agents that mainly affect fluid and electrolyte homeostasis. In the kidney, ADM has diuretic and natriuretic effects, while both ADM and PAMP directly inhibit aldosterone secretion in the adrenal gland. Adrenomedullin/ADM Protein, Human (HEK293, Fc) is the recombinant human-derived Adrenomedullin/ADM protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Adrenomedullin/ADM Protein, Human (HEK293, Fc) is 52 a.a., with molecular weight of ~39 kDa.

Human

Adrenomedullin (ADM) and PAMP are potent hypotensive and vasodilatory agents with numerous reported actions primarily linked to the physiological control of fluid and electrolyte homeostasis. In the kidney, ADM exhibits diuretic and natriuretic effects, while both ADM and PAMP inhibit aldosterone secretion through direct actions on the adrenal glands. In the pituitary gland, both peptides, at physiologically relevant doses, inhibit basal ACTH secretion. Furthermore, ADM and PAMP seem to act in the brain and pituitary gland, facilitating the loss of plasma volume, actions that complement their hypotensive effects in blood vessels. These multifaceted actions underscore the role of ADM in regulating cardiovascular and hormonal processes associated with fluid and electrolyte balance.

Pro-adrenomedullin; ADM; Adrenomedullin; AM; PAMP

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.