protein

Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His)

HY-P74413

10 μg;50 μg

200;560 USD

Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

200;560 USD

The Müllerian inhibitor/AMH protein plays a crucial role in reproductive processes. It induces degeneration of Müllerian ducts during male fetal sex differentiation and contributes to Leydig cell function. Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His) is the recombinant human-derived Muellerian-inhibiting factor/AMH protein, expressed by HEK293 , with N-His labeled tag. The total length of Muellerian-inhibiting factor/AMH Protein, Human (HEK293, His) is 536 a.a., with molecular weight of ~59.1 kDa.

Human

The Muellerian-inhibiting factor/AMH protein plays a crucial role in various reproductive functions. Specifically, it induces regression of the Muellerian ducts during male fetal sexual differentiation. It also contributes to Leydig cell differentiation and function in a similar manner. In females, it acts as a negative regulator of the transition from primordial to primary follicles and reduces the sensitivity of growing follicles to follicle-stimulating hormone. AMH exerts its signals by binding to the specific type-II receptor, AMHR2, which forms a heterodimer with type-I receptors (ACVR1 and BMPR1A). This complex recruits SMAD proteins, facilitating their translocation to the nucleus to regulate the expression of target genes. AMH itself forms homodimers through disulfide linkages.

Muellerian-inhibiting factor; AMH; MIS; MIF

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.