protein

Angiopoietin-4 Protein, Human (HEK293, Fc)

HY-P74411

2 μg;10 μg;50 μg;100 μg;500 μg

45;115;300;480;1440 USD

Angiopoietin-4 Protein, Human (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

45;115;300;480;1440 USD

Angiopoietin 4 protein (ANGPT4) critically binds to TEK/TIE2, regulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation. In addition to regulation, ANGPT4 promotes endothelial cell survival, migration, and angiogenesis. Angiopoietin-4 Protein, Human (HEK293, Fc) is the recombinant human-derived Angiopoietin-4 protein, expressed by HEK293 , with N-hFc labeled tag.

Human

The Angiopoietin-4 (ANGPT4) protein exhibits a pivotal role as it binds to TEK/TIE2, thereby modulating ANGPT1 signaling. Beyond its regulatory function, ANGPT4 has the capability to induce tyrosine phosphorylation of TEK/TIE2. Notably, it plays a crucial role in promoting endothelial cell survival, migration, and angiogenesis. Structurally, ANGPT4 exists as a homodimer, connected by disulfide linkages, highlighting its oligomeric nature. Its functional interactions with TEK/TIE2 further emphasize its integral role in orchestrating cellular processes essential for angiogenesis and vascular homeostasis.

Angiopoietin-4; AGP4; ANG-3; ANG-4; ANGPT4

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.