protein

ART3 Protein, Human (HEK293, His)

HY-P74409

5 μg;10 μg;50 μg

55;85;220 USD

ART3 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

55;85;220 USD

ART3 is a member of the mono-ADP-ribosyltransferase family genes which is involved in cell division, DNA-repair and the regulation of the inflammatory response. The temporary and restricted expression of ART3 in spermatocytes might be linked to cell division processes underlying the formation of spermatocytes and the regulation of spermatogenesis. Moreover, it induces TNBC cell growth and invasion by activating Akt and ERK. ART3 Protein, Human (HEK293, His) is the recombinant human-derived ART3 protein, expressed by HEK293 , with C-His labeled tag.

Human

ART3 is a member of the mono-ADP-ribosyltransferase family genes which is involved in cell division, DNA-repair and the regulation of the inflammatory response. ART3 mRNA can be detected in unstimulated monocytes, alveolar epithelial cells, spermatocytes in testes, macrophages, T lymphocytes and other cell types. The expression of ART3 is associated with physiological and pathological functions, including spermatogenesis and damage to the number of cardiomyocytes. The temporary and restricted expression of ART3 in spermatocytes might be linked to cell division processes underlying the formation of spermatocytes and the regulation of spermatogenesis. And ART3 protein is significantly overexpressed in human TNBC tumors tissue and cell lines through. Overexpression of ART3 in MDA-MB-231 breast cancer cells increased cell proliferation, invasion, and survival in vitro and growth of xenograft tumors by activating Akt and ERK. Moreover, ART3 may play important roles in central nervous system (CNS) pathophysiology after traumatic brain injury (TBI) [1] [2] .

Ecto-ADP-ribosyltransferase 3; ARTC3; ART3; TMART

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.