protein

B7-H4 Protein, Mouse (HEK293, His)

HY-P74394

100 μg

320 USD

B7-H4 Protein, Mouse (HEK293, His)

proteins

HEK293

100 μg

320 USD

The B7-H4 protein acts as a negative regulator and inhibits T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. Significant significance can be observed when expressed on tumor macrophages, cooperating with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Mouse (HEK293, His) is 228 a.a., with molecular weight of ~26.6 kDa.

Mouse

B7-H4 protein serves as a negative regulator of the T-cell-mediated immune response by suppressing T-cell activation, proliferation, cytokine production, and the development of cytotoxicity. Its significance is particularly pronounced when expressed on the cell surface of tumor macrophages, where it collaborates with regulatory T-cells (Treg) to play a crucial role in suppressing tumor-associated antigen-specific T-cell immunity. Beyond its immunomodulatory functions, B7-H4 is also implicated in promoting epithelial cell transformation, highlighting its involvement in diverse cellular processes associated with immune regulation and tumorigenesis.

V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice