protein

BIN1 Protein, Human (His)

HY-P74380

5 μg;10 μg;50 μg

40;65;180 USD

BIN1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

40;65;180 USD

The BIN1 protein is essential for controlling plasma membrane curvature and shape and is essential for the formation of T-tubules in muscle cells. It acts as a negative regulator of endocytosis and affects intracellular vesicle sorting. BIN1 Protein, Human (His) is the recombinant human-derived BIN1 protein, expressed by E. coli , with N-His labeled tag. The total length of BIN1 Protein, Human (His) is 424 a.a., with molecular weight of ~54 kDa.

Human

The BIN1 Protein plays a crucial role in the regulation of plasma membrane curvature, shaping, and remodeling. In muscle cells, it is indispensable for the formation of T-tubules, which are tubular invaginations of the plasma membrane critical for depolarization-contraction coupling. Acting as a negative regulator of endocytosis, BIN1 is also involved in intracellular vesicle sorting and modulates BACE1 trafficking, influencing amyloid-beta production. In neuronal circuits, its role in endocytosis regulation may impact the internalization of PHF-tau aggregates. Furthermore, BIN1 is implicated in the regulation of MYC activity, influencing cell proliferation, and exhibits actin bundling activity, stabilizing actin filaments against depolymerization. BIN1 forms a heterodimer with AMPH, binds to SH3GLB1, interacts with DNM1, SYNJ1, DNM2, AP2A2, AP2B1, MYC, BIN2, SNX4, and BACE1, indicating its involvement in diverse cellular processes and protein-protein interactions.

Myc box-dependent-interacting protein 1; BIN1; AMPHL; Amphiphysin II

Greater than 85% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCL, 200 mM NaCl, pH 8.0, 10% trehalose, 0.02% Tween80.

Room temperature in continental US; may vary elsewhere.