protein

Nucleocapsid Protein NTD domain, Virus (His)

HY-P7438

5 μg;10 μg;50 μg;100 μg

55;95;260;440 USD

Nucleocapsid Protein NTD domain, Virus (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

55;95;260;440 USD

405021308

Nucleocapsid Protein NTD domain, Virus (His) is the N-terminal RNA-binding domain (NTD) of nucleocapsid protein in coronaviruses. Nucleocapsid Protein NTD domain has highly conserved residues in the centre, which is identified as the RNA-binding site [1] .

Virus

Coronaviruses are enveloped viruses with a positive-sense RNA genomeand and has a nucleocapsid of helical symmetry. The Nucleocapsid Protein localize to the cytoplasm and the nucleolus in both virus-infected primary cells and in cells transfected with plasmids that express N protein [1] . Nucleocapsid Protein is a basic protein and is abundant in coronaviruses, which has nonspecific binding activity toward nucleic acids, including ssRNA, ssDNA, and dsDNA. Nucleocapsid Protein is an essential RNA-binding viral protein in human coronavirus (CoV)-infected cells, is required for the replication and transcription of viral RNA. Nucleocapsid Protein NTD domain has highly conserved residues in the centre, which is identified as the RNA-binding site [2] .

2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein Protein

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of PBS, 2 M Urea, pH 7.4.

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