protein

Cadherin-13 Protein, Mouse (HEK293, His)

HY-P74365

5 μg;10 μg;50 μg

45;70;180 USD

Cadherin-13 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

45;70;180 USD

Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homogeneous interactions, promote connections between adjacent cells, and may play a role in cell type sorting. Cadherin-13 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cadherin-13 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-13 Protein, Mouse (HEK293, His) is 692 a.a., with molecular weight of 90-110 kDa.

Mouse

Cadherin-13, a calcium-dependent cell adhesion protein, stands out for its unique features in comparison to classical cadherins. Unlike the typical cadherin EC1 domain strand-swapping mechanism for homodimerization, Cadherin-13 achieves this through a distinct homophilic adhesive interface, connecting two elongated EC1-EC2 domains near their Ca2+-binding sites. This arrangement forms a tetrahedral, X-like shape, showcasing a different mode of homodimerization. This protein is implicated in potentially acting as a negative regulator of neural cell growth, and its ability to preferentially interact with itself in a homophilic manner suggests a role in contributing to the sorting of heterogeneous cell types within neural tissues.

Cadherin-13; H-cadherin; T-cadherin; T-cad; CDH13

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.