protein

Calcitonin R Protein, Human (HEK293, hFc)

HY-P74359

5 μg;10 μg;50 μg

46;75;215 USD

Calcitonin R Protein, Human (HEK293, hFc)

proteins

HEK293

5 μg;10 μg;50 μg

46;75;215 USD

Calcitonin R protein, a receptor for calcitonin, utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. Calcitonin R Protein, Human (HEK293, hFc) is the recombinant human-derived Calcitonin R, expressed by HEK293 , with N-hFc labeled tag.

Human

The Calcitonin R protein serves as a receptor for calcitonin, exerting its activity through G proteins that subsequently activate adenylyl cyclase. This receptor is believed to couple with a heterotrimeric G protein sensitive to cholera toxin. However, it is noteworthy that while the Calcitonin R serves as a receptor for calcitonin, it does not effectively couple to G proteins, resulting in the inability to activate adenylyl cyclase. Additionally, following ligand binding, this receptor does not undergo the typical process of receptor internalization.

Calcitonin R; Calcitonin receptor; CALCR; CRT; CTR; CTR1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.