protein

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)

HY-P7427

10 μg;50 μg

80;220 USD

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

80;220 USD

405021298

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), with a 6His tag at the C-terminus.

Mouse

Transforming growth factor β (TGF-β) plays an important role in normal development and homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling pathways contribute to many diseases, including cancer initiation, progression, and metastasis. TGF-β ligands bind to three isoforms of the TGF-β receptor (TGFBR) with different affinities. TGFBRI and II are both serine/threonine and tyrosine kinases, but TGFBRIII does not have any kinase activity. Canonical TGF-β signaling occurs when one of the three ligands binds to TGFBRII, which then recruits and phosphorylates TGFBRI. TGFBRII is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain. The process of PTH1R-TGFBRII endocytosis was blocked using a Ser/Thr kinase-dead mutation of TGFBRII. TGFBRII directly phosphorylates proteins other than itself or TGFBRI [1] [2] .

TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized after extensive dialysis against PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.