protein

TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc)

HY-P7426

2 μg;10 μg;50 μg;100 μg;500 μg

40;114;320;540;1500 USD

TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

40;114;320;540;1500 USD

405021297

TGF-beta receptor 2 Protein, Human (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Thr23-Asp159 with an Fc tag at the C-terminus.

Human

Transforming growth factor-beta receptor type 2 (TβRII) is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain. TβRII is the specific receptor for TGFβ ligands, and crucial for the regulation of TGFβ signaling in tumor initiation, progression, and metastasis [1] . T beta R-II (transforming growth factor beta [TGF-beta] type II receptor) is a transmembrane serine/threonine kinase that acts as the primary TGF-beta receptor. Ligand binding to T beta R-II leads to the recruitment and phosphorylation of T beta R-I, a distantly related transmembrane kinase that acts as a downstream signaling component [2] .

TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, 150 mM NaCl, pH 7.4 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.