protein

Cofilin-2 Protein, Human (His)

HY-P74234

5 μg;10 μg

60;100 USD

Cofilin-2 Protein, Human (His)

proteins

E. coli

5 μg;10 μg

60;100 USD

Cofilin-2 protein controls actin polymerization and depolymerization in a pH-sensitive manner. Cofilin-2 Protein, Human (His) is the recombinant human-derived Cofilin-2 protein, expressed by E. coli , with N-His labeled tag. The total length of Cofilin-2 Protein, Human (His) is 165 a.a., with molecular weight of ~20 kDa.

Human

Cofilin-2 protein exerts reversible control over actin polymerization and depolymerization, demonstrating pH-sensitive activity. Its capacity for F-actin depolymerization is regulated through an association with CSPR3. Cofilin-2 exhibits the ability to bind both G- and F-actin in a 1:1 ratio, serving as a crucial component in the formation of intranuclear and cytoplasmic actin rods. Essential for muscle maintenance, it may play a role in the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. Additionally, Cofilin-2 interacts with CSRP3, with the intriguing possibility that two molecules of CFL2 can engage with one molecule of CSRP3.

Cofilin-2; CFL2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.