protein

VEGF164 Protein, Mouse (P.pastoris)

HY-P7421

10 μg;50 μg

115;320 USD

VEGF164 Protein, Mouse (P.pastoris)

proteins

P. pastoris

10 μg;50 μg

115;320 USD

384647089

VEGF164 Protein, Mouse (P.pastoris), a VEGF isoform splice variant, is more potent at inducing endothelial ICAM-1 expression by VEGFR-2, leukocyte migration by VEGFR-1, and inflammation and angiogenesis in the adult cornea.

Mouse

VEGF164 was found to be significantly more potent at inducing inflammation. In vivo blockade of VEGF receptor (VEGFR)-1 significantly suppressed VEGF164-induced corneal inflammation. In vitro, VEGF164 more potently stimulated intracellular adhesion molecule (ICAM)-1 expression on endothelial cells, an effect that was mediated by VEGFR2. VEGF164 was also more potent at inducing the chemotaxis of monocytes, an effect that was mediated by VEGFR1. In an immortalized human leukocyte cell line, VEGF164 was found to induce tyrosine phosphorylation of VEGFR1 more efficiently [1] . VEGF164 is an important isoform in the pathogenesis of early diabetic retinopathy [2] .

VEGF-AA; rMuVEGF164; VPF

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0.

Room temperature in continental US; may vary elsewhere.