protein

Dectin-2/CLEC6A Protein, Human (HEK293, Fc)

HY-P74201

5 μg;10 μg;50 μg

75;125;350 USD

Dectin-2/CLEC6A Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

75;125;350 USD

The Dectin-2/CLEC6A protein is a calcium-dependent lectin, a pattern recognition receptor in the innate immune system that specifically binds to Candida albicans α-mannan. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag.

Human

Dectin-2, also known as CLEC6A, functions as a calcium-dependent lectin and pattern recognition receptor (PRR) within the innate immune system, exhibiting specific recognition and binding to alpha-mannans on C. albicans hyphae. Upon binding of C. albicans alpha-mannans, this receptor complex initiates the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, thereby activating SYK, CARD9, and NF-kappa-B. This cascade of events drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells, favoring the development of effector T-helper 1 and T-helper 17 cell subtypes. In addition to its role in antifungal defense, Dectin-2 recognizes allergens from house dust mites and fungi in a mannose-dependent manner, promoting cysteinyl leukotriene production. Moreover, it plays a role in altering adaptive immune responses by recognizing soluble elements from the eggs of Schistosoma mansoni. Associated with FCER1G, Dectin-2 forms a heterodimer with CLEC4D, establishing a pattern recognition receptor against fungal infections. The multifaceted functions of Dectin-2 underscore its importance in immune surveillance and response mechanisms.

C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10

Greater than 80% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.